On August 27, 2026, the European Chemicals Agency (ECHA) announced the addition of 10 new substance testing proposals and invited public comments by October 12. ECHA’s public consultation on testing proposals is part of an open evaluation process to determine whether additional testing is required for registered chemicals.

Under the REACH Regulation, before conducting tests listed in Annex IX and X (corresponding to registration tonnage bands of 100–1,000 tonnes per year and over 1,000 tonnes per year), registrants must submit a testing proposal (TP). After the consultation period, ECHA will finalize the testing requirements based on feedback and the specific properties of the substances.

By gathering public input, ECHA aims to optimize safety assessments and revise testing requirements to align with stakeholder feedback. Registrants are obligated to carry out these tests and update their safety dossiers to ensure the safe use of chemicals and promote sustainable development in the industry.

Name

EC Number

CAS Number

Hazard endpoint for which vertebrate testing was proposed

1-Octadecanol, phosphate, potassium salt

273-489-3

68987-29-1

6.1.2 Long-term toxicity to fish

4,4'-sulphonyldiphenol

201-250-5

80-09-1

6.1.2 Long-term toxicity to fish

4-tert-butylphenol

202-679-0

98-54-4

7.8.2 Developmental toxicity / teratogenicity – Species: rabbit

Dichloromethyl(3,3,3-trifluoropropyl)silane

211-623-4

675-62-7

6.1.2 Long-term toxicity to fish

6.1.2 Long-term toxicity to fish|| Note: testing proposed with the silanol hydrolysis product Methyl(3,3,3-trifluoropropyl)silanediol (CAS 660-78-6)

7.5.1 Repeated dose toxicity: oral

7.8.2 Developmental toxicity / teratogenicity

Reaction mass of 2,4,6,8-Tetraoxanonane and 2,4,6,8,10-Pentaoxaundecane and 2,4,6,8,10,12-Hexaoxatridecane

943-163-1

-

7.5.1 Repeated dose toxicity: oral||Note: testing proposed with Reaction mass of oxymethylene dimethyl ethers, 1 < n < 5 (EC no. 935-340-7)

7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Reaction mass of oxymethylene dimethyl ethers, 1 < n < 5 (EC no. 935-340-7)

Tetramethyl orthosilicate

211-656-4

681-84-5

7.6.2 Genetic toxicity in vivo

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Further Information

ECHA