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6PPD, N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine, with CAS number 793-24-8, serves as an antioxidant and antiozonant in tires, playing a crucial safety role by protecting tire components from erosion by ozone, oxygen, and other harmful factors. However, as tires wear against the road surface during driving, particles containing 6PPD are released, which can transform into the highly toxic 6PPD-quinone upon reaction with ozone, posing risks to aquatic life.

On September 28, 2023, U.S Environmental Protection Agency (EPA) announced an important new rule under the Toxic Substances Control Act (TSCA), requiring manufacturers of per- and polyfluoroalkyl substances (PFAS) to provide more data for better regulation. PFASs are a large class of chemically stable organic fluorides known for their water and stain resistance, as well as good insulation. They find extensive use in various industrial sectors, including food packaging, electronics, leather and apparel, construction and household applications, firefighting, and medical supplies. However, PFASs are persistent and migrate in the environment, making them difficult to degrade. They are also called persistent chemicals and have posed a significant threat to human health and the ecological environment.

In July 2023, the U.S. Environmental Protection Agency (EPA) issued the final rule on "Toxic Substances Control Act (TSCA) Requirements for Asbestos Reporting and Records" which mandates specific companies to report relevant information on asbestos and asbestos-containing products (including as impurities) manufactured (including imports) or processed in the past four years.

In October 2021, the US EPA developed a PFAS strategic roadmap. In the absence of comprehensive federal legislation, several states are developing or updating their own PFAS regulations. This article compiles the current regulatory situation. According to the OECD, PFAS are defined as any substance containing at least one perfluorinated methyl (CF3-) or methylene (-CF2-) carbon atom (with no H/Cl/Br/I attached to that carbon atom). PFAS include thousands of synthetic chemicals such as perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS). PFAS have non-stick, oil-resistant, water-resistant, and grease-resistant properties. Since the 1960s, PFAS have been used in food contact substances (FCS) in the US, including cookware, food processing equipment (such as gaskets and O-rings), processing aids for other FCS (such as reducing buildup on manufacturing equipment), and food packaging (such as a grease-resistant coating).